王喆之

一、个人简介

王喆之，男，生物技术专业教授、博士、博士生导师。现任西北濒危药材资源开发国家工程实验室主任，教育部“药用资源与天然药物化学”重点实验室主任，教育部生物学教学指导委员会委员。

二、主要研究领域及兴趣

主要从事中药生物技术、新品种选育与培育、次生代谢产物生物合成调控和代谢工程、重要功能基因克隆与功能分析、中药材有效成分分离提取和中药材规范化种植等领域的研究。目前承担国家“十二五”科技支撑计划、国家基础研究平台建设、国家发改委中药材专项等多项课题；指导陕南三市十余个县、陕西省内外十余个企业的中药材规范化种植基地建设；选育陕西地道、大宗中药材新品系20余个，育成山茱萸新品种2个（通过省级审定）；先后在《植物学报》、《科学通报》、《中国科学》、《Journal of Agricultural and Food Chemistry》、《Genomics》、《Journal of Plant Research》、《Molecular Biology Reports》、《Plant Cell, Tissue and Organ Culture》、《Journal of Pharmaceutical and Biomedical Analysis》等国内外学术刊物上发表论文200余篇，参编专著3部、教材1部，获得国家发明专利5项，获陕西省科技进步奖4项。

三、代表性论文

1. Wang DH, Chen YQ, Wang Y, Wang ZZ*. Molecular cloning and expression of two plasma membrane protein 3(SmPMP3) genes from Salvia miltiorrhiza Bunge. Russ J Plant Physiol, 2012, accepted

2. Song J, Ji YY, Xu K, Wang ZZ*. An integrated analysis of the rosmarinic acid-biosynthetic genes to uncover the regulation of rosmarinic acid pathway in Salvia miltiorrhiza.Acta Physiol Plant, 2012, Online First?

3. Wang ZJ, Cui LJ, Chen C, Liu XJ, Yan YP, Wang ZZ*. Downregulation of cinnamoyl CoA reductase affects lignin and phenolic acids biosynthesis in Salvia miltiorrhiza Bunge. Plant Mol Bio Rep, 2012, Online First

4. Hua WP,Song J,Li CQ,Wang ZZ*. Molecular cloning and characterization of the promoter of SmGGPPs and its expression pattern in Salvia miltiorrhiza. Mol Biol Rep, 2012, 39(5):5775-5783

5. Li T, Qu XY, Zhang QA, Wang ZZ*. Ultrasound-assisted extraction and profile characteristics of seed oil from Isatis indigotica Fort. Ind Crop Prod, 2012, 35: 98-104

6. Hua WP, Zhang Y, Song J, Zhao LJ, Wang ZZ*.De novo transcriptome sequencing in Salvia miltiorrhiza to identify genes involved in the biosynthesis of active ingredients. Genomics, 2011, 98:272-279

7. Zheng P, Zhang KJ, Wang ZZ*. Genetic diversity and gentiopicroside content of four Gentiana species inChinarevealed by ISSR and HPLC methods. Biochem Syst Ecol, 2011, 39:704-710

8. Song J, Wang ZZ*. RNAi-mediated suppression of the phenylalanine ammonia-lyase gene in Salvia miltiorrhiza causes abnormal phenotypes and a reduction in rosmarinic acid biosynthesis. J Plant Res, 2011, 124: 183-192

9. Zhang YN,Yue XF, Wang ZZ*. Supercritical CO2 extraction and GC-MS analysis of the volatile components from Gastrodia elata. Chem Nat Comp, 2011, 46:950-952

10. Zhang Y, Yan YP, Wang ZZ*. The Arabidopsis PAP1 transcription factor plays an important role in the enrichment of phenolic acids in Salvia miltiorrhiza. J Agr Food Chem, 2010, 58, 12168-12175

11. Yan YP, Wang ZZ*, Tian W, et al. Generation and analysis of expressed sequence tags from the medicinal plant Salvia miltiorrhiza. SciChinaLife Sci 2010, 53, 273-285

12. Zhang Y, Wang ZZ*.Comparative analysis of essential oil components of two Pinus species fromTaibaiMountaininChina. Nat Prod Commun, 2010, 5, 1295-1298

13. Cao XY, Wang ZZ*. Simultaneous determination of four iridoid and secoiridoid glycosides and comparative analysis of Radix Gentianae Macrophyllae and their related substitutes by HPLC. Phytochem Anal, 2010, 21, 348-354

14. Kang JF, Zhang Y, YL Du, Wang ZZ*. Chemical composition and antimicrobial activity of the essential oils from Chloranthus japonicus Sieb. and Chloranthus multistachys Pei. Z Naturforsch, 2010,65c, 660-666

15. Zhang YN, Yue XF, Wang ZZ*. Simultaneous determination of six free fatty acids in alcohol extract of Panax japonicus  C. A.   Mey. var.   major（Burk.）C. Y. Wu et K. M. Feng with gas chromatography-mass spectrometry. J Anal Chem, 2010，65:1091-1095

16. Zhang Y, Li X, Wang ZZ*. Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents. Food Chem Toxicol, 2010, 48, 2656-2662

17. Song J, Wang ZZ*. Molecular cloning, expression and characterization of a phenylalanine ammonia-lyase gene (SmPAL1) from Salvia miltiorrhiza. Mol Biol Rep, 2009, 36, 939-952

18. Zhang Y, Wang ZZ*. Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. CR Biologies, 2009, 332, 816-826

19. Xing Li,Wang ZZ*. Chemical composition, antimicrobial and antioxidant sctivities of the essential oil in leaves of Salvia miltiorrhiza Bunge. JEssenOil Res 2009, 21, 476-480

20. Zhang Y, Wang ZZ*. Comparative analysis of essential oil components of three Phlomis species in Qinling mountains ofChina. J Pharm Biomed Anal, 2008, 47, 213-217

21. Wang HH, Wang ZZ*, Guo WB, Comparative determination of ursolic acid and oleanolic acid of Macrocarpium officinalis (Sieb. et Zucc.) Nakai by RP-HPLC.IndCrop Prod, 2008, 28, 328-332

22. Gu W, Wei N, Wang ZZ*. LC analysis of lignans from Schisandra sphenanthera Rehd. et Wils.. Chromatographia, 2008, 67, 979-983

23. Yan YP, Wang ZZ*. Genetic transformation of the medicinal plant Salvia miltiorrhiza by Agrobacterium tumefaciens-mediated method. Plant Cell Tissue Organ Cult, 2007, 88, 175-184

24. Zhang Y, Wang ZZ*. Influence of dring methods on chemical composition of the essential oil of Glechoma longituba. Chem Nat Compd, 2007, 43, 625-628

25. Zhang YN, Wang ZZ*. Essential oil composition of Hibiscus sabdariffa fromYunnan,China. Chem Nat Compd, 2007, 43:714-715