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姓名：吴宏梅 |
职称/职务：副教授 |
电话： |
传真： |
电子信箱：hq8479@snnu.edu.cn |
研究方向：细胞生物学 |
办公地点：格物楼2102 |
一、个人简介
工作经历：
2008-2014 美国贝勒医学院 博士后
2015-2016 bevictor伟德官网 讲师
2016-至今 bevictor伟德官网 副教授
讲授课程：
本科生：细胞生物学、细胞生物学实验、蛋白质工程、细胞信号转导与调控、分子与细胞综合实验
研究生：高级细胞生物学、分子细胞生物学、肿瘤细胞生物学
科研成果概况：
主要从事蛋白质SOMU 修饰的分子机制及其在各种疾病和肿瘤发生和转移中的作用研究。主持国家自然基金2项，中央高校科研项目3项，作为第二申请人参与国家自然基金2项，陕西省科技项目1项，中央高校科研项目2项。相关研究成果发表在Cell death and differentiation、Journal of Biological Chemistry、Frontiers in oncology 、Oncogene、Proc Natl Acad Sci U S A.等国际刊物。
二、主要研究领域及兴趣
1.蛋白质SUMO修饰的分子机制及其生物学功能
2.肿瘤的发生和转移的分子和代谢机制
3.肿瘤药物治疗
三、承担的科研项目
1.主持国家自然科学基金面上项目，MCAD及其SUMO修饰调控ERK/ZEB1通路影响三阴性乳腺癌侵袭和转移的作用与机制研究（2023.1-2026.12，82273395）
2.主持国家自然科学基金青年项目，肉碱棕榈酰转移酶1(CPT1)调控脂肪酸氧化代谢促进三阴性乳腺癌转移的机制研究（2016.1-2018.12，81502531）
3.主持中央高校基本科研业务费专项资金项目，SUMO抑制剂治疗急性髓系白血病的作用机制研究（2022.6-2024.5，GK202205009）
4.主持中央高校基本科研业务费专项资金项目，MCAD调控三阴性乳腺癌EMT进程的机制研究（2019.1-2020.12，GK201903066）
5.主持中央高校基本科研业务费专项资金项目，脂酰辅酶A脱氢酶(ACADs)调控三阴性乳腺癌转移的机制研究（2016.1-2017.12，GK201603064）
6.参与中央高校基本科研业务费科技领军团队项目“蛋白质动态SUMO修饰参与急性髓系白血病进程的机制研究”（2022.1-2024.12，GK202202006）
7.参与国家自然科学基金面上项目“SUMO特异性蛋白酶3调控小鼠胚胎心脏发育的机制研究”（ 81870241，2019.1-2022.12）
8.参与国家自然科学基金面上项目“SUMO修饰调控Kv7.2/Kv7.3钾离子通道蛋白活性引起癫痫猝死的机制研究”（81671294，2017.1-2020.12）
9.参与陕西省自然科学基金面上项目“SUMO修饰影响迷走神经活性引起癫痫猝死的机制研究”（2017JM3013，2017.1-2018.12）
10.参与中央高校基本科研业务费专项资金项目，SENP2调控M电流的机制研究（2016.1-2017.12，GK201603061）
四、出版的著作
1.《家养动物体外细胞培养原理与技术》 2008科学出版社出版 参编
五、代表性论文
1.Xu Chen, Yuanyuan Qin, Yuhong Zhang, Xinyi Yang, Zhengcao Xing, Yajie Shen, Jinke Cheng, Edward Yeh, Hongmei Wu*, Yitao Qi*. SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis. Cell death and differentiation. 2022. 29(2):337-350. (*co-correspondence ).
2.Xu Chen, Yuhong Zhang, Xiang Ren, Qi Su, Yan Liu, Xing Dang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Yaya Wang, Zhantao Bai, Edward T.H. Yeh, Hongmei Wu*, Yitao Qi*. SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels. Journal of biological chemistry (*co-correspondence).
3.Yuhong Zhang, Xu Chen, Qiqi Wang, Congcong Du, Wenbin Lu, Hong Yuan, Zhenzhen Zhang, Danqing Li, Xing Ling, Xiang Ren, Yang Zhao, Qi Su, Zhengcao Xing, Yuanyuan Qin, Xinyi Yang, Yajie Shen, Hongmei Wu*, Yitao Qi*. Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology. Journal of molecular medicine (*co-correspondence).
4.Xu Chen, Yuanyuan Qin, Zhenzhen Zhang, Zhengcao Xing, Qiqi Wang, Wenbin Lu, Hong Yuan, Congcong Du, Xinyi Yang, Yajie Shen, Biying Zhao, Huanjie Shao, Xiaotong Wang, Hongmei Wu*, Yitao Qi*. Hyper-SUMOylation of ERG is essential for the progression of acute myeloid leukemia. Frontiers in molecular biosciences 8(2021): 1-15. (*co-correspondence).
5.Biying Zhao, Zhenzhen Zhang, Xu Chen, Yajie Shen, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Shanshan Zhang, Xiaojun Long, Yuhong Zhang, Siming An, Hongmei Wu*, Yitao Qi*. The important roles of protein SUMOylation in the occurrence and development of leukemia and clinical implications. Journal of Cellular Physiology. 236 (2021): 3466-3480. (*co-correspondence)
6.Yuanyuan Qin, Hong Yuan, Xu Chen, Xinyi Yang, Zhengcao Xing, Yajie Shen, Wanying Dong, Siming An, Yitao Qi*, Hongmei Wu*. SUMOylation wrestles with the occurrence and development of breast cancer. Frontiers in oncology .11(2021): 1-11.
7.Xu Chen, Yuhong Zhang, Qiqi Wang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Hongmei Wu*, Yitao Qi*. The function of SUMOylation and its crucial roles in the development of neurological diseases. The FASEB Journal 35(4)(2021): 1-17. (*co-correspondence).
8.Xiaojun Long, Biying Zhao, Wenbin Lu, Xu Chen, Xinyi Yang, Jifang Huang, Yuhong Zhang, Siming An, Yuanyuan Qin, Zhengcao Xing, Yajie Shen, Hongmei Wu*, Yitao Qi*. The critical roles of the SUMO-specific protease SENP3 in human diseases and clinical implications. Frontiers in physiology 11 (2020): 1-14. (*co-correspondence).
9.Xu Chen, Shanshan Zhang, Jifang Huang, Wanying Dong, Hui Xiao, Huanjie Shao, Jinke Cheng, Hongmei Wu*, Yitao Qi*. Hyper-SUMOylation of K+ channels in sudden unexplained death in epilepsy: Isolation and primary culture of dissociated hippocampal neurons from newborn mice for subcellular localization. Methods in molecular biology. (*co-correspondence).1684 (2018): 63-71.
10.Hongmei Wu, Jiong Bi, Yan Peng, Lei Huo, Xiaobin Yu, Zhihui Yang, Yunyun Zhou, Li Qin, Yixiang Xu, Lan Liao, Yang Xie, Orla M. Conneely, Jos Jonkers and Jianming Xu. Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer. Oncotarget. 2017; 8(33):54364-54377.
11.Hongmei Wu, Xu Chen, Jinke Cheng, Yitao Qi* SUMOylation and Potassium Channels: Links to Epilepsy and Sudden Death. Advances in Protein Chemistry and Structural Biolog. 103 (2016): 295-321.
12.Abu-Elheiga L, Wu H*, Gu Z, Bressler R, Wakil SJ. Acetyl-CoA Carboxylase 2-/- Mutant Mice Are Protected Against Fatty Liver Under High-fat, High-carbohydrate Dietary and De Novo Lipogenic Conditions (*Co-first author). Journal of Biological Chemistry. 2012,287 (15): 12578-88,
13.Wu H, Guan W, Li H, Ma Y. Establishment and characteristics of white ear lobe chicken embryo fibroblast line and expression of six fluorescent proteins in the cells. Cell Biology International. 2008,.32:1478-1485
14.Wu H, Cheng D, Wang L. Association of polymorphisms of Nramp1 gene with immune function and production performance of large white pig. Journal of Genetics and Genomics. 2008,35(2):91-95.
15.Yixiang Xu, Li Qin, Tong Sun, Hongmei Wu, Tao He, Zhihui Yang, Qianxing Mo, Lan Liao, and Jianming Xu. Twist1 Promotes Breast Cancer Invasion and Metastasis by Silencing Foxa1 Expression. Oncogene. 2017 February 23; 36(8): 1157–1166.
16.Jinhui Zhou, Yitao Qi, Hongmei Wu, et al. Simultaneous determination of trace migration of phthalate esters in honey and royal jelly by gas chromatography with mass spectrometry. Journal of Separation Science. 37 (2014): 650-657.
17.Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-γ-linolenic acid. Proc Natl Acad Sci U S A.2011 Sep 20; 108 (38):15757-62.
18.Sun SF, Pan QZ, Hui X, Zhang BL, Wu HM, Li H, Xu W, Zhang Q, Li JY, Deng XM, Chen JW, Lian ZX, Li N. Stronger in vitro phagocytosis by monocytes-macrophages is indicative of greater pathogen clearance and antibody levels in vivo. Poultry Science. 2008, 87:1725-1733.
19.陈徐，赵洋，齐以涛，吴宏梅。SUMO修饰在神经系统疾病中的作用机制。生命的化学。41(5) (2021): 951-963。
20.邢正操，樊秋菊，吴宏梅。肿瘤干细胞的代谢。中国生物化学与分子生物学报。2020，36（9）：1041-1047
